BrachyClip Technology

A comprehensive solution for minimally invasive intra-operative permanent seed brachytherapy, specifically designed for open, laparoscopic, and robotic procedures.

ACCURATE

Precisely targeted radiation delivery to high-risk surgical margins

Optimized Dosimetry

Advanced planning ensures optimal dose distribution to tumor bed while minimizing exposure to healthy tissue

Predictable Outcomes

Consistent seed placement enables reproducible dosimetry calculations and treatment planning

Real-Time Verification

Radiopaque titanium markers allow for immediate imaging confirmation of placement

BrachyClip handheld applicator device with titanium clip detail

Clinical Impact

Accurate radiation delivery reduces the need for additional interventions and improves patient outcomes through targeted treatment of at-risk tissue.

Key Requirements for IPSB

"Prior techniques have been related to poor apposition of radioactive seeds. BrachyClip assures persistent placement and appropriate delivery of planned radiation."

Dr. Philip M. Devlin
Professor of Radiation Oncology
Harvard Medical School

Accurate seed placement

via any surgical approach

Secure fixation to ensure

efficacious dose distribution

Ability to precisely conform

IPSB to the residual margin

Minimal or no personnel

risk of radiation exposure

A Platform, Not Just a Product

BrachyClip's modular design enables continuous innovation and expansion beyond current brachytherapy applications

AI-Driven Imaging Tools

Integration with advanced imaging and artificial intelligence for real-time surgical margin assessment and treatment planning optimization.

Alternative Payloads

The BrachyClip delivery mechanism can accommodate various therapeutic payloads beyond traditional brachytherapy seeds.

Multi-Tumor Applications

Designed for adaptability across multiple solid tumor types, expanding addressable market opportunities.

Beyond Brachytherapy

While BrachyClip addresses an immediate clinical need in surgical margin management, its platform architecture positions the company for long-term growth through continuous innovation in targeted intra-operative therapeutics.

Monte Carlo Dosimetry Analysis

Advanced computational modeling validates BrachyClip's precise and uniform radiation dose distribution

Single Seed Dose Distribution

Monte Carlo simulation showing single seed dose distribution heatmap

Relative dose distribution from a single BrachyClip seed showing concentrated, predictable radiation delivery

20-Seed Array Dose Distribution

Monte Carlo simulation showing 20-seed array dose distribution heatmap

Combined dose distribution from a 20-seed BrachyClip array demonstrating uniform coverage of the target area

Dose Uniformity — Above Clip (Y=+1cm)

3D surface plot showing dose uniformity above the BrachyClip

Absorbed dose 1cm directly above the seed: 0.203 Rad/hr/mCi — demonstrating highly uniform dose delivery

Dose Uniformity — Below Clip (Y=-1cm)

3D surface plot showing dose uniformity below the BrachyClip

Absorbed dose 1cm directly below the seed: 0.158 Rad/hr/mCi — confirming symmetric radiation penetration