Clinical Evidence
Over 80 years of clinical efficacy and safety data supporting IPSB
Intra-Operative Permanent Seed Brachytherapy
Proven Clinical Benefits
Most frequently employed when surgical margins are close or positive
Highly effective and minimally toxic "boost" dose of irradiation maximizes local tumor control
Over 80 years of clinical efficacy and safety data
The Clinical Challenge
IPSB, though highly effective, is underutilized because current techniques are not adaptable to minimally invasive surgical procedures.
Annual U.S. cases with close/positive margins
Positive surgical resection and close (<2mm)
Local tumor recurrence cases annually
"Local tumor recurrence has a profound impact on the ability to cure cancer. It requires multidisciplinary management that is expensive and rarely successful. The best strategy to manage local tumor recurrence is to do everything possible to avoid it."
Dr. Douglas Arthur
Professor and Chairman, Department of Radiation Oncology
Massey Cancer Center, Virginia Commonwealth University
Clinical Evidence
Endorsed by Leading Clinicians
Key opinion leaders recognize BrachyClip's potential to transform surgical margin management
“With the rise of minimally invasive, robotic surgical techniques, IPSB became impractical and forgotten. BrachyClip gives us back a powerful tool to minimize the risk of local tumor recurrence.”
Dr. Gyan Pareek
Chief of Urology, Lifespan Hospitals; The Warren Alpert Medical School at Brown University; President, Brown Urology
“With BrachyClip, the potential benefit is so large and the risk of complications so low that I am tempted to use them on every patient.”
Dr. Scott Kelley
Surgical Oncologist at Watson Clinic; Chief of General Surgery at Lakeland Regional Medical Center
Projected Clinical Impact
Projected annual healthcare savings from reduced re-excisions and complications
Local control rates through precise radiation delivery to high-risk margins
Patient burden with single-procedure treatment vs. repeat surgeries
Comparison to Alternative Treatments
BrachyClip offers significant advantages over external beam radiation therapy (IMRT, SBRT) and systemic treatments:
- ✓Single intra-operative treatment vs. weeks of daily radiation
- ✓Localized radiation minimizes systemic side effects
- ✓Lower total cost than extended radiation courses
- ✓Improved quality of life with reduced treatment burden
What Experts Are Saying
With the rise of minimally invasive, robotic surgical techniques, IPSB became impractical and forgotten. BrachyClip gives us back a powerful tool to minimize the risk of local tumor recurrence.
Dr. Gyan Pareek
Chief of Urology, Lifespan Hospitals
The Warren Alpert Medical School at Brown University
President, Brown Urology
With BrachyClip, the potential benefit is so large and the risk of complications so low that I am tempted to use them on every patient.
Dr. Scott Kelley
Surgical Oncologist at Watson Clinic
Chief of General Surgery at Lakeland Regional Medical Center
Prior techniques have been related to poor apposition of radioactive seeds. BrachyClip assures persistent placement and appropriate delivery of planned radiation.
Dr. Philip M. Devlin
Professor of Radiation Oncology
Harvard Medical School
BrachyClip Will Improve Outcomes
- ✓Projected to reduce local tumor recurrence by approximately one-third
- ✓Potential healthcare savings of ≅ $2 Billion per year
- ✓Adequate reimbursement codes already in place